John Gist (d. 1778) was a planter who in 1745 leased 106 acres on the east side of Dogue Run from Sampson Darrell—land that came under GW’s ownership after his purchase of 500 acres from Darrell in 1757. Gist continued to rent his quarter from GW until 12 Aug. 1760, when GW bought out his lease. Gist apparently later moved to Loudoun County, Virginia.

Gist's mother, Ann Gist, lived on the land that Gist leased. The two made occasional use of the blacksmith at Mount Vernon (see Ledger A, 79, 95).